research proposal is the formal description of this process. The first part of the proposal will include the research question to be answered along with a TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway.
Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumorpromoting effects. The basic function of p53 is to respond to cellular stress.
The specific aim of this research proposal is to determine whether or not p53, a protein intimately associated with DNA damage repair, is inappropriately localized to the nuclear lamina and thus associated with progerin. If you have any troubles with writing a research proposal, we are here to help you!
The team of highly skilled experts is always available for you! We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53based therapy for human cancer. A Sample Research Proposal with Comments A research project or thesis will take at P53 research proposal two semesters to complete. Prior to starting a research, i.
e. Dr. Ute Moll, in front, in the Stony Brook Medicine lab where p53 research is conducted. With Dr. Moll is Postdoctoral Fellow Dr. Evguenia Alexandrova, center, first P53 research proposal on the paper; and PosDoctoral Fellow Dr. Alisha Yallowitz, shared first author. A fiveyear, 1. 8 million grant (R01CA ) from the National Cancer Institute awarded to Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, will support research to further elucidate the mechanisms behind the most frequently mutated gene in human tumors p53.
The p53 gene plays a crucial role in the way a tumour responds to chemotherapy. The major task of our research group is to set out for the clinical application of p53 as predictive marker in cancer therapy.